▀ ░
▄▄▀ ░ ▀ ▄▓
▄ ▄▄▄██▓▓█▀▄▄ ░ ▀█▓▄ ░▄▄▀ ▐█▌ ▄▄█▀ ░
▀██▓▓▌ ███▓▓▄ ▀ ▐████▄▄▄▄██▓▓█▀▄▄██▓▄▄██▓▌ ▄█▓▀
▐██▓▓ ▐██▓▓ ▀▄ ▄ ▀▄▄ ▀▀▀ ██▓▓▌ ██▓▓ ▀▀ ███▓
██▓▓▌ ██▓▓▌ ▄ ▄█▀▀▀███▄▄░ ▀▀▀▀███▓▓▄ ▐██▓▓ ▐█▓▓▌ ▀▓▄▄ ▀█▌
░ ▄▄▓▀ ▐██▓▓ ██▓▓ ▀▀▄▄ ▀▀▀ ▀██▓▓▓ ▀███▓▓ ▐██▓▓▄ ██▓▓▌▐█▓▓ ░██▓▄
▓█▓▓ ██▓▓▌▐▓▓▌▐█▄▄ ▀█▄▄ ▀▀▀▓▓▌ ▐██▓▓▌▐███▓ ▀▀▀ ▐██▓▓ ▓▓▌ ▐██▓▓
██▓▓░ ▐██▓▓ ▓▓ ██▓ ▀███▓▓▀ ▓▄▄▄▄ ▀▀▀▀▀▐██▓▌ ▄▄█▓▓▓▀▀▀██▓▓▌▓▓ ███▓▓▌
▐███▓▓ ██▓▓▌▐▌▐█▓▌ ▐██▓▓ █▓▀▀▀ ▄▄▄ ██▓▓ ████▓▓░ ▐██▓▓ ▌ ████▓▓▓
█████▓▓ ▐██▓▓ ▐█▓▌ ██▓▓▌▐▓▌ ▀██▓▓▌▐██▓▌▐███▓▓▌ ██▓▓▌ ▄▄████▓▓▓▌
▐█████▓▓▄▄▄███▓▓▓ █▓▓▌ ▐██▓▓ █▓ ▐██▓▓▐█▓▓ ███▓▓ ▐██▓▓ ███▓▓▓▓▀▀
▀▀▓████▓▓▓▀▀▀ ▀▀█▄▄▄██▓▓▌██▓█▄██▀▀▀▀▀ ▀▀▀ ▀▀███▄▄▄▄████▓▓▓ ▀▀▀▀ ░
░ ▀▀▀▀ ░ ░ ▐██▓▓ ▀▀ ▀▀▀ ░
█▄▄ ▄▄▄▄██▓▄ ██▓▓▌ ┌──────────────────────────────┐ ▄▄█
▐███▓█▄▄ ░ ▐████▓▓░ ▐██▓▓ │I drive way too fast to worry │ ░ ▄▄█▓███▌
██▀▀▀██▓▓▄ ███▓▓ ██▓▓▌ │about cholesterol. │ ▄▓▓██▀▀▀██
▄▀ ▄▄ ▐█▓▓▌ ▀███▄▄▄███▓▓ │ │ ▐▓▓█▌ ▄▄ ▀▄
▀▓▀▄██▓▀ ▀▀██▄ └──────────────────────────────┘ ▀▓██▄▀▓▀
▄▄█▀▀ ▄▄▄▄ ▄▄▄▄ ▀▀█▄▄
▄ ▀▓█▄▄░ ▀▀▀▀▀▀▀██▄ ▄██▀▀▀▀▀▀▀ ░▄▄█▓▀ ▄
▀▀▀▀▀███▓▄▄░ ▀█ █▀ ░▄▄▓███▀▀▀▀▀
░▄▄▀▀ ██▓▓ ▐▌ ▐▌ ▓▓██ ▀▀▄▄░
▄▄█▓▀ ▄▄██▓▓▀ ▀▓▓██▄▄ ▀▓█▄▄
███▓▌ ▄▄▄██▓▀▀ ░ ▀ ▀ ░ ▀▀▓██▄▄▄ ▐▓███
▀███▓███▓▀▀ ■■ The diGERATi Present ■■ ▀▀▓███▓███▀
▀▀▀
█▄▄▄▄▄ Lipid_Data_Analyzer_v1.5.1_Linux_Incl_Keygen-DIGERATI ▄▄▄▄▄▄█
▀███▓▄ ▄███▓▀
▐██▓▓ ■ ■ ███▓▌
███▀ ■■ Release Info ■■ ▀██▓
▄██▀ ▀██▄
▄██▀ ▀██▄
▐█▓▓ Cracker ......: DIGERATI Release-Type..: Incl_Keygen ██▓▌
██▓▌ Packager......: DIGPACKER Release-Date..: 11/23/2010 ▐██▓
██▓ Supplier......: DIGERATI Protection....: Time Limit ██▓
▐██ Coder.........: DIGERATI OS............: Linux █▓▌
██▓ ░ Company.......: Files.........: xx/03 ░▓█▓
▀██░ ░█▓▀
▀██░ URL: http://genome.tugraz.at/lda ░█▓▀
▓▄ ▐█▓▌ ▐█▓▌ ▄▓
█▓ ▓▓ ▀ ░ ▄▄▄▄ ▄▄▄▄ ░ ▀ ▓▓ ▓█
▒▒▄ ▀█ ▀█▓▄ ▐▓▄ ▀▀▀▄ ▄▀▀▀ ▄▓▌ ▄▓█▀ █▀ ▄▒▒
░░ ▀█▄▄▄ ▐█▓▌ ▀█▓▄ ▀ ■ ■ ▀ ▄█▓▀ ▐▓█▌ ▄▄▄█▀ ░░
█▄ █▄▀▀████▓▀ ▐█▓▌ ▀ ■■ Release Notes ■■ ▀ ▐█▓▌ ▀▓████▀▀▄█ ▄█
▄█▓ ▄▄▄ ▄▄█▓▀ ▀█▓▄▄ ▄▄▄ █▓▄
▄█▓▀ ▀██████▓▀ ▀▓████▓▓▀ ▀█▓▄
██▓ ▀▀▀ ░ ░ ▀▀▀ ██▓
▐█▓▌ ▐█▓▌
██▓ ██▓
██▓ The accurate measurement of the lipidome permits insights ██▓
██▓ into physiological and pathological processes. Of the ██▓
██▓ present high-throughput technologies, LC-MS especially ██▓
██▓ bears potential of monitoring quantitative changes in ██▓
██▓ hundreds of lipids simultaneously. In order to extract ██▓
██▓ valuable information from huge amount of mass spectrometry ██▓
██▓ data, the aid of automated, reliable highly sensitive and ██▓
██▓ specific analysis algorithms is indispensable. ██▓
██▓ ██▓
██▓ We present here a novel approach for the quantitation of ██▓
██▓ LC-MS data. The new algorithm obtains its analytical power ██▓
██▓ by two major innovations: 1) a 3D algorithm that confines ██▓
██▓ the peak borders in m/z and time direction and 2) the use ██▓
██▓ of the theoretical isotopic distribution of an analyte as ██▓
██▓ selection/exclusion criterion. The algorithm is integrated ██▓
██▓ in the Lipid Data Analyzer (LDA) application, which ██▓
██▓ additionally provides standardisation, a statistics module ██▓
██▓ for results analysis, a batch mode for unattended analysis ██▓
██▓ of several runs and a 3D viewer for the manual ██▓
██▓ verification. ██▓
██▓ ██▓
██▓ The statistics module offers sample grouping, tests ██▓
██▓ between sample groups and export functionalities, where ██▓
██▓ the results are visualised by heat maps and bar charts. ██▓
██▓ The presented algorithm has been applied to data from a ██▓
██▓ controlled experiment and to biological data, containing ██▓
██▓ analytes distributed over an intensity range of 10^6. Our ██▓
██▓ approach shows improved sensitivity and an extremely high ██▓
██▓ positive predictive value compared to existing methods. ██▓
██▓ Consequently, this application is a valuable improvement ██▓
██▓ in the high-throughput analysis of lipids. ██▓
██▓ ██▓
██▓ ██▓
██▓ ██▓
██▓ ██▓
██▓ ██▓
██▓ ██▓
▐█▓▌ ▐█▓▌
██▓ ░ ▄ ▀▀▄ ■ ■ ▄▀▀ ▄ ░ ▓█▓
▀██▓▄▄ ▐██▄ ▄ ■■ Install Notes ■■ ▄ ▄█▓▌ ▄▄▓██▀
▄▀▀████▄█▓▓▀▀ ▄▄ ▄▄ ▀▀ ██▓▄████▀▀▄
▄█▌ ▄▄▄ ▀▀▀████▄▄▀▀ ▀▀▄▄████▀▀▀ ▄▄▄ ▐█▄
██▓ ▀ ▐█▌ ▐█▌ ▀ █▓▓
▀██▓▄▄█▓ █▓▄▄██▓▀
▄ ▀▀▀▀▀ ▀▀▀▀▀ ▄
█▓ █▓▀ ▀▓█ █▓
█▓▌▀█ 1. Unpack and install the software █▀▐█▓
█▓▌▀█ 2. Run keygen.html to create your own serial -or- if you're █▀▐█▓
█▓▌▀█ lazy, use info in serial.txt █▀▐█▓
██▓▌ ▐██▓
▄██ ██▄
▐█▓▌ ▄██▄ ▄▄█▓▄▄ ▄▄▀▀■ ■▀▀▄▄ ▄▄██▓▄ ▄██▄ ▐█▓▌
▐█▓ ▄▄█▓▀ ▄▄▄ ▀██▓▀ ▀▄▄▀ ▀▄▄▀ ▀██▓▀ ▄▄▄ ██▓▄▄ █▓▌
▀███▓▓ ▀▀ ▀▀▀▀██▓▓▓▀
▄▄▄▄█ ■■ Mission Statement: ■■ █▄▄▄▄
▄█▓ █▓▌ A few years ago, DiGERATi emerged onto the scene. ▐█▓ █▓▄
█▓▌ ▐█▓ Focusing on quality rather than quantity, our █▓▌ ▐█▓
▀█▓ █▓▌ members have successfully tackled some of the toughest ▐█▓ █▓▀
▀▀▄ █▓▌ challenges in the scene. Working as a closely unified ▐█▓▄▀▀
▐█▓ team we have maintained some of the highest standards ██▓
██▓██ for security, quality, innovation, and comradery in the ██ ██▓
▐█▓ ▐█ scene today. DiGERATi is not one or two hardworking ▓▌ █▓▌
█▓ █▓ persons; it is a force of hardworking people. Respect ██▓ █▓
█▓ █▓▓ is not to be demanded; it is to be earned! We look ██▓ █▓
▄█▓ ▄█▓▓ forward to working even harder in the future to continue ██▓▄ █▓▄
▐█▓▌ ██▓▓ & to earn the respect of our peers. For anyone other than ██▓▓ ▐█▓▌
▐██▓ ██▓▀ our peers, WE DO NOT EXIST! ▀██▓██▓▓
▀███▄▄▄░ ░▄▄▄█▓▓▀
▄▄▀▀▀█▓█▄▄▄ ░ ░ ▄▄▄█▓█▀▀▀▄▄
█▓▌ ▀█▓▓▓▄▄ ▄█ ▄▄███▓▀ ▐▓█
▀█▄ ▐██▓▓▓▌ ░ ░ █ █ ▀ █▀▀ ▓▀▄ ▄▀▀ ▀█ █▄▄ █ ░ ░ ▐███▓▓▌ ▄█▀
▄▄▄▄▄▀▀▀▀▀▀▀▓▀ ░ ░ █▄▓░█░█▄█ █▄▄ █ ░█▄▓ █▄▄ █ ░ ░ ▀▓▀▀▀▀▀▀▀▄▄▄▄▄
█▓▓▀ ░ ░ ▀▓▓█
█▓▓▀ ░ ░ ▀▓▓█
▐▓▌ ▓▌
▐▓▌ ■■ Our Respect goes out to: ■■ ▓▌
▐▓▌ ▓▌
▀█▄▄ BliZZARD BRD CORE CRD DELIGHT DVT DDU EAT F4CG EMBRACE ▄█▀
▄▄▄▄█ HAZE HERETIC LZ0 SHOCK SSG TBE UNDERPL ZWT █▄▄▄▄
▄▄▄▄█ █▄▄▄▄
▄█▓ █▓▌ ■ Greets to all who work hard help make the scene secure! ▐█▓ █▓▄
▄█▓ █▓▌ ▐█▓ █▓▄
█▓▌ ▐█▓ ■ A special thanks to those who supported us in the past and █▓▌ ▐█▓
▀█▓ █▓▌ helped to make us what we are today.Also,a major thanks to ▐█▓ █▓▀
▀▀▄ █▓▌ those that broke the trail for us but can no longer be ▐█▓ ▄▀▀
▐█▓ here amongst us. █▓▌
██▓ █ ███▓
▐█▓ ▐█ ■ Who are the "digerati" and why are they "the cyber elite"? ▓ █▓▌
█▓ █▓ They are the doers and thinkers. They are not on the ██▓ █▓
█▓ █▓▓ frontier, they are the frontier!!... ██▓ █▓
▄█▓ ▄█▓▓ ██▓▄ █▓▄
▐█▓▌ ██▓▓ ██▓▓ ▐█▓▌
▐██▓ ██▓▀ ▀██▓ ██▓▓
▀███▄▄▄░ ░▄▄▄█▓▓▀
▄▄▀▀▀█▓█▄▄▄ ░ ░ ▄▄▄█▓█▀▀▀▄▄
█▓▌ ▀█▓▓▓▄▄ ▄█ ▄▄███▓▀ ▐▓█
▀█▄ ▐██▓▓▓▌ ░ ░ █ █ ▀ █▀▀ ▓▀▄ ▄▀▀ ▀█ █▄▄ █ ░ ░ ▐███▓▓▌ ▄█▀
▄▄▄▄▄▀▀▀▀▀▀▀▓▀ ░ ░ █▄▓░█░█▄█ █▄▄ █ ░█▄▓ █▄▄ █ ░ ░ ▀▓▀▀▀▀▀▀▀▄▄▄▄▄
█▓▓▀ ░ ░ ▀▓▓█
▐▓▌ Yce ▐▓▌
▀█▄▄ ▄█▀