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▐███▓█▄▄ ░ ▐████▓▓░ ▐██▓▓ │Don't sweat petty │ ░ ▄▄█▓███▌
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▀███▓███▓▀▀ ■■ The diGERATi Present ■■ ▀▀▓███▓███▀
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█▄▄▄▄▄ Genesis_v1.7.6.30.09.10-DIGERATI ▄▄▄▄▄▄█
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▐██▓▓ ■ ■ ███▓▌
███▀ ■■ Release Info ■■ ▀██▓
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▐█▓▓ Cracker ......: DIGERATI Release-Type..: Regged ██▓▌
██▓▌ Packager......: DIGPACKER Release-Date..: 10/9/2010 ▐██▓
██▓ Supplier......: DIGERATI Protection....: License ██▓
▐██ Coder.........: DIGERATI OS............: WinALL █▓▌
██▓ ░ Company.......: Files.........: xx/11 ░▓█▓
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▀██░ URL: genome.tugraz.at ░█▓▀
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█▄ █▄▀▀████▓▀ ▐█▓▌ ▀ ■■ Release Notes ■■ ▀ ▐█▓▌ ▀▓████▀▀▄█ ▄█
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██▓ High throughput gene expression analysis is becoming more ██▓
██▓ and more important in many areas of biomedical research. ██▓
██▓ cDNA microarray technology is one very promising approach ██▓
██▓ for high throughput analysis and gives the opportunity to ██▓
██▓ study gene expression patterns on a genomic scale. ██▓
██▓ Thousands or even tens of thousands of genes can be ██▓
██▓ spotted on a microscope slide and relative expression ██▓
██▓ levels of each gene can be determined by measuring the ██▓
██▓ fluorescence intensity of labeled mRNA hybridized to the ██▓
██▓ arrays. Hence, microarrays can be used to identify ██▓
██▓ differentially expressed genes in two samples on a large ██▓
██▓ scale. Beyond simple discrimination of differentially ██▓
██▓ expressed genes, functional annotation ██▓
██▓ (guilt-by-association) or diagnostic classification ██▓
██▓ requires the clustering of genes from multiple experiments ██▓
██▓ into groups with similar expression patterns. Several ██▓
██▓ clustering techniques were recently developed and applied ██▓
██▓ to analyze microarray data. ██▓
██▓ We have developed a platform independent Java package of ██▓
██▓ tools to simultaneously visualize and analyze a whole set ██▓
██▓ of gene expression experiments. After reading the data ██▓
██▓ from flat files several graphical representations of ██▓
██▓ hybridizations can be generated, showing a matrix of ██▓
██▓ experiments and genes, where multiple experiments and ██▓
██▓ genes can be easily compared with each other. Fluorescence ██▓
██▓ ratios can be normalized in several ways to gain a best ██▓
██▓ possible representation of the data for further ██▓
██▓ statistical analysis. We have implemented hierarchical and ██▓
██▓ non hierarchical algorithms to identify similar expressed ██▓
██▓ genes and expression patterns, including: 1) hierarchical ██▓
██▓ clustering, 2) k-means, 3) self organizing maps, 4) ██▓
██▓ principal component analysis, and 5) support vector ██▓
██▓ machines. More than 10 different kinds of similarity ██▓
██▓ distance measurements have been implemented, ranging from ██▓
██▓ simple Pearson correlation to more sophisticated ██▓
██▓ approaches like mutual information. Moreover, it is ██▓
██▓ possible to map gene expression data onto chromosomal ██▓
██▓ sequences. The flexibility, variety of analysis tools and ██▓
██▓ data visualizations, as well as the free availability to ██▓
██▓ the research community makes this software suite a ██▓
██▓ valuable tool in future functional genomic studies. ██▓
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██▓ ░ ▄ ▀▀▄ ■ ■ ▄▀▀ ▄ ░ ▓█▓
▀██▓▄▄ ▐██▄ ▄ ■■ Install Notes ■■ ▄ ▄█▓▌ ▄▄▓██▀
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█▓ █▓▀ ▀▓█ █▓
█▓▌▀█ 1. Unpack and install the software █▀▐█▓
█▓▌▀█ 2. Use the following information in serial.txt to register █▀▐█▓
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▄▄▄▄█ ■■ Mission Statement: ■■ █▄▄▄▄
▄█▓ █▓▌ A few years ago, DiGERATi emerged onto the scene. ▐█▓ █▓▄
█▓▌ ▐█▓ Focusing on quality rather than quantity, our █▓▌ ▐█▓
▀█▓ █▓▌ members have successfully tackled some of the toughest ▐█▓ █▓▀
▀▀▄ █▓▌ challenges in the scene. Working as a closely unified ▐█▓▄▀▀
▐█▓ team we have maintained some of the highest standards ██▓
██▓██ for security, quality, innovation, and comradery in the ██ ██▓
▐█▓ ▐█ scene today. DiGERATi is not one or two hardworking ▓▌ █▓▌
█▓ █▓ persons; it is a force of hardworking people. Respect ██▓ █▓
█▓ █▓▓ is not to be demanded; it is to be earned! We look ██▓ █▓
▄█▓ ▄█▓▓ forward to working even harder in the future to continue ██▓▄ █▓▄
▐█▓▌ ██▓▓ & to earn the respect of our peers. For anyone other than ██▓▓ ▐█▓▌
▐██▓ ██▓▀ our peers, WE DO NOT EXIST! ▀██▓██▓▓
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▀█▄ ▐██▓▓▓▌ ░ ░ █ █ ▀ █▀▀ ▓▀▄ ▄▀▀ ▀█ █▄▄ █ ░ ░ ▐███▓▓▌ ▄█▀
▄▄▄▄▄▀▀▀▀▀▀▀▓▀ ░ ░ █▄▓░█░█▄█ █▄▄ █ ░█▄▓ █▄▄ █ ░ ░ ▀▓▀▀▀▀▀▀▀▄▄▄▄▄
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▐▓▌ ■■ Our Respect goes out to: ■■ ▓▌
▐▓▌ ▓▌
▀█▄▄ BliZZARD BRD CORE CRD DELIGHT DVT DDU EAT F4CG EMBRACE ▄█▀
▄▄▄▄█ HAZE HERETIC LZ0 SHOCK SSG TBE UNDERPL ZWT █▄▄▄▄
▄▄▄▄█ █▄▄▄▄
▄█▓ █▓▌ ■ Greets to all who work hard help make the scene secure! ▐█▓ █▓▄
▄█▓ █▓▌ ▐█▓ █▓▄
█▓▌ ▐█▓ ■ A special thanks to those who supported us in the past and █▓▌ ▐█▓
▀█▓ █▓▌ helped to make us what we are today.Also,a major thanks to ▐█▓ █▓▀
▀▀▄ █▓▌ those that broke the trail for us but can no longer be ▐█▓ ▄▀▀
▐█▓ here amongst us. █▓▌
██▓ █ ███▓
▐█▓ ▐█ ■ Who are the "digerati" and why are they "the cyber elite"? ▓ █▓▌
█▓ █▓ They are the doers and thinkers. They are not on the ██▓ █▓
█▓ █▓▓ frontier, they are the frontier!!... ██▓ █▓
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▐▓▌ Yce ▐▓▌
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